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Interested in our L-5-Methyltetrahydrofolate Calcium? Fill out the form below to request a quote, sample, or additional technical information.
Your Trusted Partner: Best L-5-Methyltetrahydrofolate Calcium Supplier & Manufacturer
Welcome to the premier destination for high-purity, bioactive folate ingredients. As a leading best L-5-Methyltetrahydrofolate Calcium supplier, we specialize in providing premium-grade L-5-Methyltetrahydrofolate Calcium (L-5-MTHF-Ca), the advanced and bioidentical form of folate. This essential nutrient, also known as L-Methylfolate or active folate, is crucial for numerous metabolic processes, including DNA synthesis, amino acid metabolism, and the critical remethylation of homocysteine. For brands seeking a reliable wholesale L-5-Methyltetrahydrofolate Calcium supplier with uncompromising quality, our products represent the gold standard in efficacy, stability, and bioavailability.
Premium L-5-Methyltetrahydrofolate Calcium: Product Overview
Our L-5-Methyltetrahydrofolate Calcium (C10), specifically the Calcium salt of (6S)-5-methyltetrahydrofolic acid, is a superior alternative to synthetic folic acid. It is the predominant, circulating form of folate in the human body and is directly usable in biological pathways, bypassing the need for conversion by the MTHFR enzyme. This makes it vital for individuals with MTHFR polymorphisms. As a dedicated best L-5-Methyltetrahydrofolate Calcium food grade manufacturer, we ensure our product meets the strictest standards for both dietary supplements and fortified foods.
- Product Name: L-5-Methyltetrahydrofolate Calcium
- Synonyms: (6S)-5-Methyltetrahydrofolic acid, calcium salt; L-Methylfolate Calcium; Metafolin® (Brand Equivalent)
- CAS No.: 151533-22-1
- Molecular Formula: C20H21CaN7O6 • nH2O
- Appearance: Yellow to orange-yellow powder
- Assay (HPLC): ≥98.0%
- Main Application: Dietary supplements, food fortification, infant formula, pharmaceutical preparations.
Specifications & Quality Standards of Our L-5-Methyltetrahydrofolate Calcium
Our commitment as a best L-5-Methyltetrahydrofolate Calcium manufacture is validated by rigorous quality control. The following table details our comprehensive product specifications, ensuring transparency and confidence for your product development.
| Test Item | Specification | Test Method |
|---|---|---|
| Description | Yellow to orange-yellow powder | Visual |
| Identification (HPLC) | Conforms to Reference Standard | HPLC |
| Assay (Anhydrous Basis) | 98.0% ~ 102.0% | HPLC |
| Water Content (Karl Fischer) | ≤ 8.0% | KF Titration |
| Related Substances (Total Impurities) | ≤ 2.0% | HPLC |
| Residual Solvents | Complies with ICH Q3C | GC |
| Heavy Metals (as Pb) | ≤ 10 mg/kg | ICP-MS |
| Lead (Pb) | ≤ 0.5 mg/kg | ICP-MS |
| Arsenic (As) | ≤ 0.5 mg/kg | ICP-MS |
| Cadmium (Cd) | ≤ 0.5 mg/kg | ICP-MS |
| Mercury (Hg) | ≤ 0.1 mg/kg | ICP-MS |
| Total Aerobic Microbial Count | ≤ 1000 CFU/g | USP <61> |
| Total Yeast & Mold Count | ≤ 100 CFU/g | USP <61> |
| E. Coli | Negative / 10g | USP <62> |
| Salmonella | Negative / 25g | USP <62> |
Broad Applications of L-5-MTHF Calcium
As a versatile best L-5-Methyltetrahydrofolate Calcium food grade supplier, our ingredient is engineered for success across multiple industries. The superior stability and bioavailability of our Methylfolate calcium make it the ideal choice for innovative product formulations.
1. Dietary Supplements
The primary market for active folate. Ideal for:
- Prenatal & Women’s Health: Supports healthy fetal development and maternal well-being.
- Cardiovascular Health: Key for healthy homocysteine metabolism.
- MTHFR Support: Directly usable form for individuals with MTHFR gene variants.
- Comprehensive B-Complex & Multivitamins: The modern, bioavailable source of folate.
- Mental Wellness Formulas: Supports neurotransmitter synthesis.
Typical Usage Level: 400 mcg to 1000 mcg per serving in supplements.
2. Food & Beverage Fortification
Our food-grade quality allows for seamless integration into various products, complying with global fortification guidelines.
- Breakfast Cereals & Nutritional Bars
- Fortified Juices, Dairy, and Plant-Based Milk Alternatives
- Bakery Products & Pasta
- Special Dietary Foods
Usage Recommendation: Levels vary by food matrix and regional regulations. Consultation advised.
3. Pharmaceutical & Infant Nutrition
Meeting the highest purity standards for sensitive applications.
- Pharmaceutical Preparations: For prescription medical foods and specific therapeutic formulations.
- Infant Formula: Provides the bioactive form of folate crucial for early development, mirroring the folate profile in human milk.
- Clinical Nutrition Products
We are a strategic Quatrefolic supplier alternative, offering high-quality 5-MTHF for MTHFR support in these critical segments.
Synergistic Nutrient Matrix for Optimal Efficacy
Folate does not work in isolation. L-5-Methyltetrahydrofolate is a central player in the homocysteine methylation cycle. For formulations targeting comprehensive metabolic support, consider these synergistic ingredients available from our portfolio:
- Methylcobalamin (Active B12): Works directly with L-5-MTHF to recycle homocysteine into methionine. Using the active forms of both folate and B12 ensures maximum efficiency, especially for those with genetic polymorphisms.
- Betaine (Trimethylglycine): Provides an alternative pathway for homocysteine remethylation, supporting the primary folate/B12 pathway and reducing metabolic burden.
- Vitamin B2 (Riboflavin) & Vitamin B6 (Pyridoxal-5-Phosphate): Essential cofactors for the enzymes (MTHFR and CBS, respectively) involved in folate metabolism and homocysteine transsulfuration.
- Zinc: A crucial cofactor for numerous enzymes in methylation and DNA synthesis. Adequate zinc status is vital for optimal function of the methylation cycle.
Formulation Tip: Combining our premium L-5-MTHF-Ca with Methylcobalamin, Betaine, and cofactor vitamins B2 and B6 creates a powerful, science-backed formula for supporting healthy homocysteine levels and overall methylation status.
Packaging & Storage
To preserve the stability and potency of this sensitive ingredient, we use specialized packaging:
- Primary Packaging: 1 kg aluminum foil bag with double polyethylene liners. Options for vacuum or nitrogen flushing are available to minimize oxidation.
- Secondary Packaging: Sealed in a cardboard drum or box for robust transportation.
- Custom Packaging: As a flexible wholesale L-5-Methyltetrahydrofolate Calcium food grade supplier, we can discuss custom sizes (e.g., 5kg, 10kg, 25kg) to suit your production scale.
- Storage: Store in a cool, dry place (below 25°C/77°F). Keep the container tightly sealed and protected from light and moisture. Shelf life is typically 24 months when stored properly.
Certifications & Quality Assurance
Your trust is our priority. Our identity as a reliable best L-5-Methyltetrahydrofolate Calcium manufacture is built on a foundation of internationally recognized certifications and a stringent Quality Management System.
ISO Certified
Our facility operates under an ISO-certified quality management system, ensuring consistent and documented processes from raw material to finished product.
Kosher Certified
Our product holds Kosher certification, meeting the dietary requirements of Jewish law and expanding your product’s market appeal.
Halal Certified
We are proud to offer Halal-certified L-5-MTHF Calcium, compliant with Islamic dietary laws and suitable for global Muslim populations.
Frequently Asked Questions (FAQ)
Folic acid is a synthetic, oxidized form that must be converted by the body (via the MTHFR enzyme) into the active form, L-5-MTHF. L-5-Methyltetrahydrofolate Calcium is the reduced, bioactive, and body-identical form. It is directly usable in metabolic pathways, making it superior for individuals with impaired MTHFR enzyme function and ensuring guaranteed bioavailability for everyone.
We distinguish ourselves as the best L-5-Methyltetrahydrofolate Calcium supplier through an unwavering focus on quality, evidenced by our ≥98% HPLC purity, strict heavy metal limits, and full suite of certifications (ISO, Kosher, Halal). We offer technical expertise on formulation and synergistic ingredients like methylcobalamin, competitive pricing for wholesale, and reliable global logistics.
Absolutely. We are a specialized best L-5-Methyltetrahydrofolate Calcium food grade manufacturer. Our product is produced in a facility with food-grade compliance, and its specifications are designed to meet the requirements for fortifying a wide range of food and beverage products. Please contact us for specific application guidance.
Typical supplemental doses range from 400 mcg to 1000 mcg per day. For prenatal formulas, 400-800 mcg is common. Higher doses (e.g., 1-15 mg) may be used in specialized medical foods under clinical guidance. It is crucial to formulate within the regulatory limits of your target market.
We employ multiple strategies: manufacturing under controlled, low-oxygen environments, using light-protective and moisture-proof packaging (aluminum bags with nitrogen flushing available), and providing clear storage guidelines. Our stability data confirms a 24-month shelf life when stored correctly in unopened packaging.
How to Choose the Right L-5-Methyltetrahydrofolate Calcium Supplier
Selecting a partner for this critical ingredient requires careful evaluation. Here are key points to consider:
1. Purity & Analytical Documentation
Insist on Certificates of Analysis (CoA) with detailed HPLC assay (aim for ≥98%), impurity profiles, and heavy metal testing. A transparent best L-5-Methyltetrahydrofolate Calcium manufacture will provide full specs.
2. Quality Certifications
Verify relevant certifications like ISO (for QMS), Kosher, Halal, and if needed, GRAS or other regulatory filings. These are non-negotiable for market access.
3. Technical & Regulatory Support
Can the supplier advise on formulation stability, synergistic blends (e.g., with B vitamins), and regional compliance? This support is invaluable.
4. Scalability & Reliability
Assess their production capacity, consistency of supply, and logistical network. A true wholesale L-5-Methyltetrahydrofolate Calcium supplier can support your growth from R&D to full-scale production.
Request Your Sample & Quote Today
Ready to formulate with premium, bioactive folate? Partner with a supplier that combines scientific rigor with supply chain excellence. Contact us now to discuss your project requirements, request a complimentary sample, or get a competitive quote.
📞 Phone: +86-27-8329 8801
📱 Email: contact@nutrition-ingredients.net
🌐 Our Partner for Comprehensive Solutions: www.srikro.com
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