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Premium Inosine & Inosine Monophosphate Supplier for Global Supplement & Food Industries
Inosine (Inosine Monophosphate): A Nucleotide Powerhouse
Inosine, also known as Inosine Monophosphate (IMP), is a naturally occurring nucleoside that plays crucial roles in cellular energy transfer, protein synthesis, and neurological function. As a leading best Inosine supplier, we provide high-purity Inosine that serves as a vital intermediate in purine metabolism and ATP regeneration pathways. Our product is manufactured under strict pharmaceutical-grade standards, making it suitable for demanding applications in dietary supplements, functional foods, and clinical nutrition.
Chemically classified as a purine nucleoside, Inosine consists of hypoxanthine linked to a ribose sugar moiety. This molecular structure enables it to participate in numerous biochemical processes, including energy production, RNA synthesis, and cellular signaling. The global market for nucleotide-based ingredients has seen significant growth, driven by increasing consumer awareness of cellular health and energy metabolism support.
- Product Name: Inosine (Inosine Monophosphate, IMP)
- CAS No.: 58-63-9 (Inosine); 131-99-7 (IMP)
- Molecular Formula: C10H12N4O5 (Inosine)
- Molecular Weight: 268.23 g/mol
- Appearance: White to off-white crystalline powder
- Solubility: Soluble in hot water, slightly soluble in cold water
- Assay (HPLC): ≥ 98.0%
- Loss on Drying: ≤ 1.0%
- Heavy Metals: ≤ 10 ppm
Download the complete technical specification sheet for detailed quality parameters and analytical methods.
Technical Specifications & Quality Standards
As a premier best Inosine manufacture, our quality control protocol begins with rigorous raw material screening and continues through every stage of synthesis, purification, and micronization. The following comprehensive specification table details the exacting standards that define our pharmaceutical-grade Inosine, suitable for the most demanding applications in human nutrition and clinical formulations.
| Test Parameter/Item | Specification Standard | Test Method | Significance/Notes |
|---|---|---|---|
| Identification (HPLC/IR) | Conforms to reference standard | USP/Ph.Eur. | Confirms molecular identity and purity |
| Assay (Inosine content) | 98.0% – 101.0% | HPLC (UV detection) | Primary potency measurement |
| Appearance | White or almost white crystalline powder | Visual inspection | Visual quality indicator |
| Specific Rotation [α]²⁰D | -49° to -52° (c=1 in H₂O) | Polarimetry | Confirms stereochemical purity |
| pH (1% aqueous solution) | 5.5 – 7.0 | Potentiometric | Acidity/alkalinity balance |
| Loss on Drying | ≤ 1.0% (105°C, 3h) | Gravimetric | Moisture content measurement |
| Residue on Ignition | ≤ 0.1% | Gravimetric (800°C) | Inorganic impurity assessment |
| Heavy Metals (as Pb) | ≤ 10 mg/kg | USP <231> | Toxic metal contamination limit |
| Arsenic (As) | ≤ 2 mg/kg | ICP-MS | Toxic element limit |
| Related Substances (HPLC) | Total impurities ≤ 1.0% Any single impurity ≤ 0.5% | HPLC (UV 254nm) | Purity assessment from byproducts |
| Microbiological Quality | Total aerobic count ≤ 1000 cfu/g Yeast & Mold ≤ 100 cfu/g E. coli: Absent in 1g Salmonella: Absent in 10g | USP <61>, <62> | Microbiological safety parameters |
| Particle Size Distribution | 90% ≤ 150μm (optional) | Laser diffraction | For specific formulation requirements |
Our commitment as a wholesale Inosine supplier extends beyond basic compliance. Each production batch undergoes approximately 35 separate quality control checks before release, ensuring unprecedented consistency and reliability for your formulations. All shipments are accompanied by a comprehensive Certificate of Analysis (CoA) that documents compliance with these exacting standards, along with supporting stability data and method validation reports upon request.
The manufacturing process utilizes advanced enzymatic synthesis and purification technologies that minimize byproduct formation while maximizing yield and purity. Our state-of-the-art facilities operate under cGMP (current Good Manufacturing Practice) guidelines, with dedicated production lines for nucleotide ingredients to prevent cross-contamination. Regular third-party audits and analytical verification ensure our internal quality systems meet or exceed international standards including USP, EP, JP, and FCC.
Applications & Usage Recommendations: Dietary Supplements, Foods & Functional Beverages
Inosine serves as a versatile bioactive ingredient with scientifically supported benefits across multiple product categories. As a specialized best Inosine food grade supplier, we provide technical guidance for optimal incorporation into your product matrix while maintaining stability, bioavailability, and regulatory compliance. The following detailed application analysis covers the primary utilization categories with specific formulation recommendations.
Dietary Supplements & Sports Nutrition
Inosine functions as a purine nucleoside precursor that supports ATP regeneration, cellular energy production, and exercise performance. Clinical studies suggest potential benefits for endurance athletes and individuals seeking metabolic support.
- Sports Performance Formulas: Often combined with creatine, beta-alanine, and electrolytes in pre-workout and recovery products. Enhances ATP availability during high-intensity exercise.
- Energy & Metabolism Support: Incorporated into comprehensive metabolic formulas with B-vitamins, CoQ10, and carnitine for mitochondrial support.
- Neurological Health Supplements: Emerging research suggests neuroprotective potential when combined with other nucleosides (uridine, cytidine) in cognitive formulations.
- Cardiovascular Support: Investigated for supporting cardiac energy metabolism in specialized heart health formulations.
Typical Usage Level: 250-1000 mg per daily serving in divided doses. For sports performance, 500-1500 mg taken 30-60 minutes before exercise. Always consider individual tolerance and consult clinical research for specific applications.
Functional Foods & Medical Nutrition
Inosine serves as a nucleotide source in specialized nutritional products, particularly those targeting cellular repair, immune modulation, and metabolic conditions.
- Enteral & Parenteral Nutrition: Component of nucleotide-enriched medical foods for postsurgical recovery, trauma, and immunocompromised patients.
- Geriatric Nutrition: Incorporated into age-specific formulations targeting mitochondrial function and cellular repair mechanisms.
- Infant Formula (specialized): Nucleotide-fortified formulas where permitted by regulation, supporting immune development and gastrointestinal maturation.
- Functional Beverages: Energy drinks, recovery beverages, and cognitive support drinks where nucleotide supplementation is indicated.
Usage in Foods: Generally 0.02-0.1% in finished products (200-1000 mg/kg). For medical nutrition, follow clinical guidelines (typically 0.5-1.5 g/day in divided doses). Heat stability considerations: add post-processing when possible; Inosine is relatively heat-stable up to 120°C for short periods.
Research & Pharmaceutical Applications
Beyond nutraceutical uses, Inosine serves as a valuable intermediate in pharmaceutical synthesis and as an active ingredient in investigational therapies.
- Pharmaceutical Intermediate: Starting material for synthesis of antiviral agents (particularly nucleoside analogs) and other purine-based pharmaceuticals.
- Clinical Research Material: Provided to research institutions studying neurological repair, ischemic preconditioning, and immunomodulation.
- Diagnostic Reagents: Component of specialized biochemical assays and diagnostic kits.
- Cell Culture Applications: Supplement in specialized cell culture media for particular cell lines requiring nucleotide sources.
Pharmaceutical Grade: Our cGMP-compliant Inosine meets ICH Q7 guidelines for pharmaceutical ingredients. For research use, we provide detailed characterization data including NMR, MS, and chiral purity verification. Custom purity grades (≥99.5%) available for critical applications.
Formulation Considerations & Compatibility
Successful incorporation of Inosine into product formulations requires attention to several technical factors:
- Solubility Profile: Inosine demonstrates moderate water solubility (approximately 1.5 g/100mL at 20°C), significantly improving with temperature increase (to approximately 15 g/100mL at 100°C). For beverage applications, pre-dissolving in warm water (60-70°C) is recommended before incorporation into the final product matrix.
- pH Stability: Optimal stability in pH range 5.5-7.0. Avoid strongly acidic conditions (pH < 3) which may accelerate hydrolysis. In alkaline conditions (pH > 8.5), gradual degradation may occur over extended periods.
- Compatibility with Other Ingredients: Generally compatible with most supplement and food ingredients. No known incompatibilities with common excipients. However, avoid strong oxidizing agents in direct contact.
- Storage Stability: When stored in original sealed containers at controlled room temperature (15-25°C) and low humidity (<60% RH), Inosine maintains stability for at least 36 months. Protect from direct light exposure and excessive moisture.
- Bioavailability Enhancement: Absorption occurs primarily in the small intestine via nucleoside transporters. Formulation with lipid-based delivery systems has shown potential to enhance bioavailability in preclinical models.
Packaging, Storage & Global Logistics
As a reliable wholesale Inosine food grade supplier serving global markets, we offer flexible, secure packaging solutions designed to maintain product integrity throughout the supply chain while meeting international shipping and regulatory requirements.
Standard Packaging Configuration
- Primary Packaging: Double-layer polyethylene bags with aluminum foil inner liner (0.1mm thickness) providing excellent moisture and oxygen barrier properties.
- Secondary Packaging: Food-grade fiberboard drum (25 kg net weight) or HDPE plastic drum with airtight sealing mechanism. Each drum includes desiccant packet (silica gel, food-grade) to control moisture.
- Labeling: Compliant with international regulations including product name, batch number, manufacturing date, expiry date, storage conditions, net weight, and hazard symbols (where applicable). Custom labeling available to meet specific country requirements.
- Palletization: Standard configuration: 16 drums per pallet (400 kg net weight), stretch-wrapped with corner protectors for secure transport. Euro pallets or standard pallets available based on destination requirements.
Custom & Small-Quantity Packaging
Understanding that different customers have varying requirements, we offer multiple alternative packaging options:
- Small Quantity Options: 1 kg aluminum foil bags, 5 kg HDPE containers, or 10 kg cartons for R&D samples and small production runs.
- Bulk Packaging: For large-volume customers, 500 kg or 1000 kg flexible intermediate bulk containers (FIBCs) with appropriate liners are available, offering significant cost savings for high-volume users.
- Custom Branding: Private label packaging with your company branding, logos, and customized labeling information compliant with your market regulations.
- Documentation Package: Each shipment includes Certificate of Analysis, Material Safety Data Sheet (MSDS), Certificate of Origin, Commercial Invoice, and Packing List. Additional documentation (GMP Certificate, Stability Data, Allergen Statement) available upon request.
Storage & Handling Guidelines
- Optimal Storage Conditions: Store in a cool, dry, well-ventilated area away from direct sunlight. Maintain temperature between 15-25°C and relative humidity below 60%.
- Shelf Life: 36 months from date of manufacture when stored under recommended conditions in original unopened packaging.
- Re-Opened Containers: After opening, reseal immediately and use contents promptly. For partially used containers, transfer remaining material to airtight containers with desiccant.
- Handling Precautions: Use appropriate personal protective equipment (dust mask, gloves, safety glasses) when handling powder to minimize dust inhalation and contact. Ensure adequate ventilation in handling areas.
- Transportation: Classified as non-hazardous for transport by air, sea, or land. No special shipping requirements under normal conditions.
Global Logistics Support
With extensive experience in international ingredient distribution, we provide comprehensive logistics solutions:
- Shipping Options: FOB, CIF, CFR, DAP, DDP based on your preference and incoterms understanding.
- Primary Routes: Regular container shipments from major Chinese ports (Shanghai, Ningbo, Shenzhen) to destinations worldwide.
- Documentation Expertise: Experienced in documentation requirements for major markets (EU, USA, Canada, Australia, Japan, Southeast Asia, South America).
- Cold Chain Capability: Temperature-controlled logistics available for customers requiring strict temperature maintenance during transit.
- Tracking & Communication: Real-time shipment tracking and proactive notification of any transit issues or delays.
Certifications & Quality Assurance: Our Commitment to Excellence
Our identity as a trusted best inosine monophosphate supplier is validated by a comprehensive suite of internationally recognized certifications and quality management systems. These credentials demonstrate our unwavering commitment to producing ingredients that meet the highest standards of safety, purity, and consistency for global markets.
ISO 9001:2015
Quality Management System
KOSHER Certified
Year-round certification
HALAL Certified
MUI Halal certification
Comprehensive Quality Management System
Beyond these visible certifications, our quality assurance framework encompasses every aspect of production and supply:
- cGMP Compliance: Our manufacturing facilities operate under current Good Manufacturing Practice guidelines for pharmaceutical ingredients, with dedicated quality assurance teams conducting regular internal audits and procedure reviews.
- Documentation & Traceability: Complete batch traceability from raw materials to finished product, with comprehensive documentation maintained for a minimum of 5 years beyond product expiration.
- Stability Testing Program: Ongoing real-time and accelerated stability studies conducted according to ICH guidelines to establish and verify shelf-life claims under various storage conditions.
- Method Validation: All analytical methods are fully validated for specificity, accuracy, precision, linearity, range, and robustness according to ICH Q2(R1) guidelines.
- Supplier Qualification: Rigorous qualification process for all raw material suppliers with periodic requalification audits and testing of incoming materials.
- Change Control System: Formal change control procedures ensure that any modifications to processes, equipment, or materials are properly evaluated, documented, and validated before implementation.
- Customer Complaint Management: Systematic investigation and response process for any customer quality concerns, with root cause analysis and corrective/preventive actions implemented to prevent recurrence.
- Regulatory Intelligence: Active monitoring of global regulatory developments affecting nucleotide ingredients to ensure ongoing compliance with evolving requirements in all target markets.
Third-Party Verification & Audits
Our quality claims are substantiated by regular third-party verification:
- Independent Laboratory Testing: Annual testing by internationally accredited third-party laboratories to verify product specifications and analytical method accuracy.
- Customer Audits: We welcome and facilitate customer quality audits of our facilities, with over 15 successful audits conducted annually by multinational food, supplement, and pharmaceutical companies.
- Regulatory Inspections: Our facilities have successfully passed inspections by various national regulatory authorities for exports to regulated markets.
- Certification Surveillance: Annual surveillance audits by certification bodies to maintain ISO, Kosher, and Halal certifications with zero major non-conformities in the past 5 years.
Request our complete Quality Manual, Audit Reports, or Certification Documents for your supplier qualification process.
Frequently Asked Questions (FAQ) About Inosine
Inosine is a nucleoside consisting of hypoxanthine linked to a ribose sugar. Inosine Monophosphate (IMP) is the phosphorylated form containing an additional phosphate group attached to the ribose moiety. In practical terms for most supplement and food applications, the terms are often used interchangeably, though precise biochemical distinctions exist. Our product line includes both forms, with technical guidance available on which form may be more suitable for specific applications based on solubility, stability, and metabolic considerations.
Current scientific literature suggests several potential applications for Inosine supplementation. Research areas include: 1) Exercise performance and recovery, with studies showing potential benefits for endurance athletes; 2) Neurological support, with preclinical evidence suggesting neuroprotective effects; 3) Cardiovascular health, related to its role in purine metabolism and ATP regeneration in cardiac tissue; 4) Immune modulation, as nucleotides including Inosine may support immune function under certain conditions. However, regulatory positions on specific health claims vary by jurisdiction. We provide comprehensive scientific dossiers summarizing available evidence for product development and regulatory submission purposes.
Typical dosage in human supplementation ranges from 250 mg to 1500 mg daily, often divided into two or three doses. For athletic performance applications, studies have used 500-1500 mg taken approximately 30-60 minutes before exercise. For general wellness or metabolic support, lower doses of 250-500 mg daily are common. However, optimal dosing depends on the specific application, formulation matrix, and target population. We recommend consulting clinical literature specific to your intended use and conducting appropriate safety assessments during product development. Our technical team can provide formulation guidance based on published research and industry experience.
Inosine demonstrates good stability under typical formulation conditions but requires attention to several factors: 1) pH stability is optimal between 5.5-7.0, with potential degradation in strongly acidic conditions; 2) Thermal stability is generally good up to 120°C for short periods, but prolonged exposure to higher temperatures should be avoided; 3) Moisture sensitivity requires appropriate packaging with moisture barriers; 4) Light exposure should be minimized, though Inosine is not exceptionally photosensitive. For challenging formulations, we offer stability testing services and can provide specific recommendations based on your product matrix and processing conditions. Our standard product has demonstrated 36-month shelf stability when stored properly.
Regulatory status varies significantly by jurisdiction: 1) United States: Generally recognized as safe (GRAS) for specific uses, or as a dietary supplement ingredient under DSHEA; 2) European Union: May be considered a novel food in some applications, with specific member state regulations; 3) Canada: Natural Health Product ingredient with specific licensing requirements; 4) Japan: Listed in Japanese Standards of Food Additives; 5) Australia/New Zealand: Permitted in listed supplements. Regulatory status is application-specific and evolving. We maintain current regulatory intelligence on major markets and can provide guidance documents, but ultimate regulatory compliance responsibility lies with the product manufacturer for their specific market and claims.
How to Select a Reliable Inosine Supplier: Key Evaluation Criteria
Choosing the right best Inosine supplier is a critical business decision that impacts product quality, regulatory compliance, supply chain reliability, and ultimately your brand reputation. Based on decades of industry experience serving global customers, we recommend evaluating potential suppliers against the following comprehensive criteria:
1. Technical Capability & Manufacturing Expertise
Assess the supplier’s production technology, purification methods, and scale capabilities. A true best Inosine manufacture should utilize advanced enzymatic or fermentation processes rather than basic chemical synthesis, resulting in superior purity profiles. Evaluate their R&D investment, process validation documentation, and technical support capabilities for formulation challenges.
2. Quality Systems & Certifications
Verify beyond certificate display to understand actual quality system implementation. Request quality manual excerpts, recent audit reports (internal and third-party), and evidence of robust change control, deviation management, and CAPA systems. For best inosine monophosphate supplier selection, pharmaceutical-grade certifications (cGMP) indicate higher standards than basic food-grade facilities.
3. Regulatory Compliance & Documentation
A competent supplier should demonstrate understanding of global regulatory landscapes. Evaluate their experience with your target markets, ability to provide comprehensive documentation packages (CoA, MSDS, stability data, allergen statements, GMO-free certificates), and responsiveness to regulatory inquiries. For wholesale Inosine food grade supplier relationships, verify他们对 major market requirements.
4. Supply Chain Transparency & Traceability
Investigate raw material sourcing, supply chain controls, and traceability systems. A transparent best Inosine food grade manufacture should provide information about raw material origins, intermediate suppliers, and complete supply chain documentation. Assess their business continuity planning, raw material inventory strategies, and response capability during market disruptions.
5. Testing & Analytical Capabilities
Examine the supplier’s in-house analytical capabilities versus outsourcing. A sophisticated wholesale inosine monophosphate supplier should maintain modern instrumentation (HPLC, GC-MS, ICP-MS) with validated methods and qualified personnel. Review their testing frequency, reference standard qualifications, and approach to method transfer for customer verification testing.
6. Customer Support & Technical Service
Evaluate pre-sales and post-sales support responsiveness, technical expertise availability, and problem-solving approach. A reliable partner provides formulation assistance, regulatory guidance, and rapid response to quality inquiries. Consider their communication effectiveness, language capabilities, and cultural alignment with your organization.
Red Flags in Supplier Evaluation
During your assessment process, be cautious of suppliers who:
- Cannot provide recent third-party Certificates of Analysis for their products
- Have inconsistent documentation or evasive responses to technical questions
- Offer prices significantly below market without clear justification
- Lack transparency about their manufacturing process or facility location
- Cannot provide references from established companies in regulated markets
- Have poor communication practices or unprofessional responsiveness
- Display limited understanding of regulatory requirements in your target markets
- Cannot demonstrate adequate insurance coverage or financial stability
Our company not only meets but exceeds these evaluation criteria, with a track record of successful partnerships with multinational corporations, mid-sized brands, and innovative startups across six continents. We invite thorough due diligence through facility audits, sample testing, and reference checks with our existing customers.
Partner with the Leading Global Inosine Supplier
Ready to source premium-quality Inosine with complete technical support and regulatory documentation? Contact our specialist team today for competitive quotations, complimentary evaluation samples, or detailed technical consultations. As an established best Inosine supplier with decades of nucleotide expertise, we support your product development from concept to commercial launch with unmatched technical guidance and supply chain reliability.
📞 Phone: +86-27-8329 8801
📱 Email: contact@nutrition-ingredients.net
🌐 Our Partner: www.srikro.com
🕒 Business Hours: Monday-Friday, 8:30 AM – 5:30 PM (CST)
✉️ Sample Requests: Available for qualified companies. Include your intended application and required quantity for appropriate sample selection.
📄 Documentation: Comprehensive technical dossiers, regulatory support documents, and formulation guidance available upon request.
Technical Specifications of Pharmaceutical Grade Inosine
- Product Name: Inosine (9-β-D-Ribofuranosylhypoxanthine)
- CAS Number: 58-63-9
- Purity: ≥98%
- Appearance: White crystalline powder
- Solubility: Slightly soluble in water
- Storage: 2-8°C in airtight container
- Shelf Life: 24 months
Download Full Specifications for Bulk Inosine Powder Supplier
Applications in Food Additives
As a professional bulk inosine supplier, our product is essential for:
- Energy drink formulations
- Sports nutrition products
- Functional food additives
- Dietary supplement manufacturing
- Medical nutrition products
Quality Certifications
Frequently Asked Questions
What’s the recommended dosage?
Typical usage ranges from 50-200mg per serving depending on application.
Is it suitable for halal products?
Yes, we provide halal-certified inosine upon request.
What’s the lead time?
Standard production time is 2-3 weeks after order confirmation.
Contact Inosine Powder Supplier
📞 Phone: +86-27-8329 8801
📱 Mobile: +86-181 8610 6808
📧 Email: contact@nutriton-ingredients.net
Certification Partner:
www.srikro.com
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